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    • 摘要: 皮肤作为人体最大的器官,有着屏障功能、免疫应答、防止水分流失和排泄废物等重要作用。大面积的严重皮肤损伤患者会由于缺乏充足的可移植皮肤而死亡。生物3D打印技术的发展为可移植皮肤的制造提供了解决办法。生物3D打印技术可以定制化制造功能性的皮肤替代品,有望解决移植皮肤短缺的困难。本文简述了皮肤创伤修复原理,比较了用于皮肤修复的生物材料墨水、细胞和主要的生物3D打印技术,分析了光电技术在3D打印皮肤上的应用潜力,并总结了生物3D打印技术在皮肤修复应用中所面临的挑战和未来的发展方向,提出了光电技术在生物3D打印中的应用需求。

       

      Abstract: The skin is the largest organ of the human body, which plays an important role in barrier function, immune response, preventing water loss and excreting waste. Patients with large-scale severe skin injuries will die due to lack of adequate skin grafts. The development of 3D bioprinting technology provides a solution for the manufacture of transplantable skin. Firstly, the principles of skin wound repairing are described. Secondly, the bioinks, cells and main 3D bioprinting technologies used in skin wound repairing are compared. Then, the opto-electronic technologies involved are analyzed, and the challenges and future development of 3D bioprinting in the application of skin repair are summarized. Finally, the application requirements of opto-electronic technology in 3D bioprinting are proposed.