Abstract: Blind deconvolution is one of the commonly used post-reconstruction methods for adaptive optics images. In order to improve the reconstruction performance of blind deconvolution on solar (adaptive optics) images, a space-variant multi-frame blind deconvolution model based on second-order total generalized variation is proposed. It first solves the proposed space-invariant blind deconvolution model via second-order total generalized variation by the alternating minimization and half-quadratic splitting method. Then, according to the characteristics of wide field-of-view solar images which are anisoplanatic, the space-variant in the proposed algorithm is implemented by overlapping image segmentation and weighted stitching. Finally, the reconstruction experiment and analysis are carried out on the real solar images observed by the one-meter New Vacuum Solar Telescope (NVST). The results show that the proposed algorithm has good image reconstruction performance in both subjective visual effects and objective indexes.