Abstract: The slippery surface inspired by Nepenthes has received research and industry attentions due to its excellent liquid repellency, stability and self-repair property. The femtosecond laser is a powerful method to prepare the slippery surfaces due to its universality in processing materials with high precision, and high controllability. In this paper, taking the lyophobicity of slippery surfaces as a background, using femtosecond laser mico/nano-manufacturing technology as a method, the development of slippery surfaces by femtosecond laser was summarized from two perspectives, including the femtosecond laser mico/nano-manufacturing and applications of slippery surfaces. By controlling the processing parameters of femtosecond laser, the slippery surfaces could be fabricated on various materials, such as polymers, hard brittle transparent material, and metals. The prepared slippery surface can be applied in the fields of droplet and bubble manipulation, biological anticoagulation, antifouling, and anti-corrosion. Finally, the challenges of slippery surfaces were summarized.