Abstract: Sweep source optical coherence tomographic angiography (SS-OCTA) is a kind of angiography technologies based on split spectrum amplitude deeorrelation angiography (SSADA). It has a great prospect in the early diagnosis of tumors and other diseases. In this paper, skin structure and angiography of melanoma C57BL6 mice were collected on the basis of the SS-OCTA imaging platform with an imaging field of 5.12 mm×5.12 mm and a standard image maximum signal-to-noise ratio of 34.3 dB. The results show that the SS-OCTA system is superior to the structural imaging in early diagnosis of dermatological diseases.