• 摘要: 眼底疾病是主要致盲原因之一,其早期精准诊断高度依赖光学成像技术,然而,传统商业化眼底成像设备存在固有像差,难以清晰呈现视网膜微观结构,导致多数眼底疾病错失最佳干预时机。自适应光学(AO)技术通过实时校正眼内动态像差,使成像分辨率突破至细胞尺度,经过二十多年的发展,自适应光学技术在眼底成像中的应用形成了多种成像模式,在功能动态监测、细胞级结构解析及断层成像中展现出独特优势。本文首先介绍了自适应光学的基本原理,综述了基于自适应光学的眼底相机(FC)、扫描激光检眼镜(SLO),以及光学相干断层扫描成像(OCT)在眼底成像中的研究与应用。在此基础上,归纳和总结了上述三种方法在多模态融合技术上的发展现状。可以预见,提高自适应光学眼底高分辨成像技术水平,完善应用体系建设并加快产业体系转化,对眼科健康的发展具有重要推动作用。

       

      Abstract: Fundus diseases is one of the leading causes of blindness globally, and its early accurate diagnosis relies heavily on optical imaging techniques. However, conventional commercial fundus imaging devices suffer from inherent aberrations, making it difficult to clearly visualize the microscopic structures of the retina and resulting in most fundus diseases missing the optimal intervention timing. Adaptive Optics (AO) technology, by real-time correcting intraocular dynamic aberrations, enables imaging resolution to break through to the cellular scale. Over more than two decades of development, the application of AO technology in fundus imaging has evolved into various imaging modalities, demonstrating unique advantages in tomographic imaging, cellular-level structural analysis, and functional dynamic monitoring. This paper first introduces the basic principles of adaptive optics, then reviews the research and applications of AO-based fundus camera (FC), scanning laser ophthalmoscopy (SLO), and optical coherence tomography (OCT) in fundus imaging. On this basis, the current status of multimodal fusion technology integrating these three approaches is summarized. It is anticipated that improving the technological level of AO-based high-resolution fundus imaging, optimizing application system development, and accelerating industrialization will play a crucial role in advancing ophthalmic healthcare in China.