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Li XD. Novel all-fiber-optic technology for control and multi-color probing of neural circuits in freely-moving animals. Opto-Electron Adv 6, 230086 (2023). doi: 10.29026/oea.2023.230086
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Novel all-fiber-optic technology for control and multi-color probing of neural circuits in freely-moving animals
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Abstract
All-fiber-optic photometry system based on a multi-branch fiber bundle has achieved, for the first time, simultaneous optogenetic manipulation and dual-color recording of neuronal Ca2+ or neurotransmitter signals in freely moving animals, providing a powerful tool for comprehensive analysis of neural circuit function and the study of neurological diseases. -
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References
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Li XD. Novel all-fiber-optic technology for control and multi-color probing of neural circuits in freely-moving animals. Opto-Electron Adv 6, 230086 (2023). doi: 10.29026/oea.2023.230086
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Figure 1.
All-fiber-transmission photometry system based on a multi-branch fiber bundle9. (a) Schematic diagram of the system; (b) Schematic diagram of animal surgery and virus injection; (c) Averaged DA signal and neuronal Ca2+ signal transients in response to unexpected sucrose solution; (d) Averaged DA signal and neuronal Ca2+ signal transients in response to phasic and tonic optogenetic stimulation. (Credit: this figure was provided by the authors of Ref.9.)
